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Curcumin may upregulate glutathione synthesis enzymes through activation of the Nrf2 antioxidant response element pathway (Balogun et al., 2003)

We use K m values in the ranges determined experimentally but there is much less information on V max values

Excess ROS can damage biomacromolecules, promote pro-inflammatory cytokine release, and skew immune differentiation, potentially exacerbating autoimmune inflammation and tissue injury [34, 35]

These assets aim to move beyond the current weekly injection paradigm, signalling a future where extended dosing intervals could become central to maintenance strategies [16]

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